Tag: Lipitor

If other cyp3a substrates drugs that are broken down by cyp3a such as simvastatin zocor , lovastatin mevacor , or atorvastatin lipitor are taken concomitantly with erythromycin, levels of the substrates increase, often causing adverse effects.

Lipitor is a selective, competitive inhibitor of hmg-coa reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme a to mevalonate, a precursor of sterols, including cholesterol.