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This medication may increase serotonin and rarely cause a very serious condition called serotonin syndromeThe risk increases if you are also taking other drugs that increase serotoninso tell your doctor or pharmacist of all the drugs you takeGet medical help right away if you develop some of the following symptomshallucinationsunusual restlessnessloss of coordinationfast heartbeatsevere dizzinessunexplained feversevere nausea/vomiting/diarrheatwitching muscle.
The bioavailability of selegiline is increased 3 to 4 fold when it is taken with food.
Serious reactions with signs and symptoms that may include diaphoresisflushingataxiahyperthermiahyper/hypotensionseizurespalpitationdizziness and mental changes that include agitationconfusion and hallucinations progressing to delirium and coma have been reported in some patients receiving a combination of selegiline and fluoxetineSimilar experience has been reported in patients receiving selegiline and two other serotonin reuptake inhibitorssertraline and paroxetineThere is a potential risk of interaction with fluvoxamine and venlafaxine.
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