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Most effective drugs against group a, b1, and b2 were gentamicin, amikacin and cefixime; ceftriaxone and quinolones; and ceftriaxone and amikacin, respectively.

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Combining cefixime with aminoglycosidesfor exampletobramycinTobradexproduces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney

Anaphylactic/anaphylactoid reactionsincluding shock and fatalitiesskin rashesurticariadrug feverpruritusangioedemaand facial edemaErythema multiformeStevens-Johnson syndromeand serum sickness-like reactions have been reported.

Increased prothrombin timewith or without clinical bleedinghas been reported when cefixime is administered concomitantly.

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