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In clinical studiesViramune has been associated with an increase in HDLcholesterol and an overall improvement in the total to HDL-cholesterol ratioHoweverin the absence of specific studiesthe clinical impact of these findings is not knownIn additionViramune has not been shown to cause glucose disturbances.
Any patient experiencing severe rash or a rash accompanied by constitutional symptoms such as feverblisteringoral lesionsconjunctivitisfacial oedemamuscle or joint achesor general malaise should discontinue the medicinal product and immediately seek medical evaluationIn these patients nevirapine must not be restarted.
Indicated for treatment of HIV-1 infection in combination with other antiretroviralsalso used for prevention of maternal-fetal HIV transmission in women with no prior antiretroviral treatment.
It is not recommended to co-administer efavirenz and Viramunesee section 4.4because of additive toxicity and no benefit in terms of efficacy over either NNRTI alonefor results of2NN studysee section 5.1
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