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In concurrent hypercalcemia and hyperphosphatemiasoft-tissue calcification may occurthis can be seen radiographicallysee WARNINGS

Calcitriol increases inorganic phosphate levels in serumWhile this is desirable in patients with hypophosphatemiacaution is called for in patients with renal failure because of the danger of ectopic calcificationA non-aluminum phosphate-binding compound and a low-phosphate diet should be used to control serum phosphorus levels in patients undergoing dialysis.

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