Substances like digoxin, morphine, amiloride, tolbutamide, fluconazole, rifampin, gemifibrozil, nsaids and certain seizure medicines may interact with actoplus met.
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Th hav bn postmakting pots atal and nonatal hpatic ailu in patints taking pioglitazon, although th pots contain insuicint inomation ncssay tstablish th pobabl caus. Th has bn nvidnc dug-inducd hpatotoxicity in th pioglitazon contolld clinical tial databas tdat [s ADVS ACTIONS ].
In contolld clinical tials mtomin 29 wks’duation, a dcas tsubnomal lvls pviously nomal sum vitamin B 12 lvls, without clinical manistations, was obsvd in appoximatly 7% patints. Such dcas, possibly du tintnc with B 12 absoption om th B 12 -intinsic actcomplx, is, howv, vy aly associatd with anmia and appas tb apidly vsibl with discontinuation mtomin vitamin B 12 supplmntation. Masumnt hmatologic paamts on an annual basis is advisd in patints on ACTOPLUS MT and any appant abnomalitis should b appopiatly invstigatd and managd. Ctain individuals (thos with inadquat vitamin B 12 calcium intak absoption) appa tb pdisposd tdvloping subnomal vitamin B 12 lvls. In ths patints, outin sum vitamin B 12 masumnts at two-tth-ya intvals may b usul.
Actoplus Mt is usd togth with dit and xcis timpov blood suga contol in adults with typ 2 diabts mllitus whdnot us daily insulin injctions.
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