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Cephalosporins may be associated with prolonged prothrombin timeThose at risk include patients with renal or hepatic impairmentor poor nutritional stateas well as patients receiving a protracted course of antibacterial therapyand patients receiving anticoagulant therapyMonitor prothrombin time in patients at risk and manage as indicated.
Careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking KEFLEX and metforminsee CLINICAL PHARMACOLOGY
Clostridium difficileassociated diarrheaCDADhas been reported with use of nearly all antibacterial agentsincluding KEFLEXand may range in severity from mild diarrhea to fatal colitisTreatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of Cdifficile
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