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The following adverse reactions have been reported with neo-medrol lozione antiacne methylprednisolone acetate or other corticosteroids .

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Areas not suitable for injection are those that are anatomically inaccessible such as spinal joints and those like the sacroiliac jointswhich are devoid of synovialspaceTreatment failures are most frequently the result of failure to enter the synovial spaceIf failures occur when injections into the synovial spaces are certainas determined by aspiration of fluidrepeated injections are usually futileLocal therapy does not alter the underlying disease processand whenever possible comprehensive therapy including physiotherapy and orthopedic correction should be employed.

Frequency not reportedBradycardiacardiac arrestcardiac arrhythmiascardiac enlargementcirculatory collapsecongestive heart failurefat embolismhypertensionhypertrophic cardiomyopathy in premature infantsmyocardial rupture following recent myocardial infarctionsyncopetachycardiathromboembolismthrombophlebitisvasculitisedemahypotensionRef]

Reversible transaminase elevationsASTALThave been observed following corticosteroid therapyThese changes have generally been small and not associated with any clinical syndromeToxic hepatitis has been reported with high doses of cyclicallypulsed IV therapyonset has been several weeks or longerResolution has been reported with discontinuationhoweverrecurrence has been reported with rechallengeRef]

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