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Drugs which induce CYP2C19 or CYP3A4such as StJohn’s Wort or rifampincan substantially decrease esomeprazole concentrationssee DRUG INTERACTIONSAvoid concomitant use of NEXIUM with StJohn’s Wort or rifampin.

Cutaneous lupus erythematosusCLEand systemic lupus erythematosusSLEhave been reported in patients taking PPIsincluding esomeprazoleThese events have occurred as both new onset and an exacerbation of existing autoimmune diseaseThe majority of PPI-induced lupus erythematosus cases were CLE.

Pathological Hypersecretory Conditions Including Zollinger-Ellis On Syndrome.

Pathological Hypersecretory Conditions Including Zollinger-Ellis On Syndrome.

NEXIUM is indicated for the long-term treatment of pathological hypersecretory conditionsincluding Zollinger-Ellison Syndrome.

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