Macrolide antibiotics including erythromycin and clarithromycin, as well as several of the newer classes of antifungals, especially of the azole class fluconazole, voriconazole , increase tacrolimus levels by competing for cytochrome enzymes.
Toyonensis strains bct-7112 t , bct-7112 tet, bct-7112 cat, and rock1-3, selecting for erythromycin resistant transformants at 37 c.
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Like erythromycin, telithromycin is both a substrate and a potent inhibitor of cyp3a4.
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For staphylococci and streptococci, isolates resistant to erythromycin but susceptible to clindamycin should be tested for inducible mls b resistance dissociated resistance 58 .
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Azithromycin belongs to the same class as erythromycin, and this type of antibiotic has a wide berth of safety.
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clindamycin; erythromycin; ampicillin;.
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