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Selegiline is indicated for the treatment of Parkinson’s diseaseor symptomatic parkinsonismIt may be used alone in early Parkinson’s disease for symptomatic relief to delaythe need for levodopawith or without decarboxylase inhibitoror as an adjunct to levodopawith or without decarboxylase inhibitorSelegiline in combination with maximal levodopa therapy is indicated particularly in patients who experience fluctuations in their condition such asend-dosetype fluctuationson-offsymptoms or other dyskinesias.
This drug may rarely cause an attack of extremely high blood pressurehypertensive crisiswhich may be fatalMany drug and food interactions can increase this riskSee also Drug Interactions sectionGet medical help right away if any of these serious side effects occurfrequent/severe headachefast/slow/irregular/pounding heartbeatchest painneck stiffness/sorenesssevere nausea/vomitingsweating/clammy skinsometimes with feverwidened pupilsvision changese.gdouble/blurred visionsudden sensitivity to lightphotophobia
The number of patients who received selegiline in prospectively monitored pre-marketing studies is limitedWhile other sources of information about the use of selegiline are availablee.gliterature reportsforeign post-marketing reportsetcthey do not provide the kind of information necessary to estimate the incidence of adverse eventsThusoverall incidence figures for adverse reactions associated with the use of selegiline cannot be providedMany of the adverse reactions seen have also been reported as symptoms of dopamine excess.
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