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Ergot-containing drugs have been reported to cause prolonged vasospastic reactionsBecause there is a theoretical basis that these effects may be additiveuse of ergotamine-containing or ergot-type medicationslike dihydroergotamine or methysergideand rizatriptan within 24 hours is contraindicatedDue to an additive effectthe concomitant use of rizatriptan and ergotamine/ergot derivativesincluding methysergideincreases the risk of coronary artery vasoconstriction and hypertensive effectsThis combination is contraindicated.
The undesirable effects observed with the administration of rizatriptan are dizzinesssomnolenceparaesthesiaheadachehypaesthesiadecreased mental acuitytremorhot flushes/flashespharyngeal discomfortdyspnoeapalpitationtachycardiapaintightness/pressure and/or heavy sensation in the chestneckthroat or jawregional heavinesspain in locations unspecifieddry mouthnauseavomitingdiarrhoeaflushingsweatingand asthenia/fatigue.
As with other 5-HT1 agonistssensations of tightnesspainpressureand heaviness in the precordiumthroatneck and jaw commonly occur after treatment with rizatriptan and are usuallynoncardiac in originHoweverif a cardiac origin is suspectedpatients should be evaluatedPatients shown to have CAD and those with Prinzmetal’s variant angina should not receive 5-HT1 agonists.
Make changes in your diet such as avoid such foodsincluding caffeine and alcohol which are believed to trigger headachesYou can also try muscle relaxation exercisesyoga or meditation to ease the migraine attack.
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