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All patients should undergo a cardiovascular evaluationincluding echocardiogram to assess the potential presence of valvular diseaseIf valvular disease is detectedthe patient should not be treated with DOSTINEXSee CONTRAINDICATIONSPostmarketing cases of cardiac valvulopathy have been reported in patients receiving DOSTINEXThese cases have generally occurred during administration of high doses of DOSTINEX2mg/dayfor the treatment of Parkinson’s diseaseCases of cardiac valvulopathy have also been reported in patients receiving lower doses of DOSTINEX for the treatment of hyperprolactinemic disorders.
Cabergoline 1 mg and 2 mg tabletsCabaserare used to treat Parkinson’s disease.
There was a slight increase in the incidence of cervical and uterine leiomyomas and uterine leiomyosarcomas in miceIn ratsthere was a slight increase in malignant tumors of the cervix and uterus and interstitial cell adenomasThe occurrence of tumors in female rodents may be related to the prolonged suppression of prolactin secretion because prolactin is needed in rodents for the maintenance of the corpus luteumIn the absence of prolactinthe estrogen/progesterone ratio is increasedthereby increasing the risk for uterine tumorsIn male rodentsthe decrease in serum prolactin levels was associated with an increase in serum luteinizing hormonewhich is thought to be a compensatory effect to maintain testicular steroid synthesisSince these hormonal mechanisms are thought to be species-specificthe relevance of these tumors to humans is not known.
This medication is used to treat high levels of prolactin hormone in your bodyHigh levels of prolactin in women can cause symptoms such as unwanted breast milk and missed periods and can cause difficulty becoming pregnantHigh levels of prolactin in men can cause symptoms such as enlarged breasts and decreased sexual ability/desireCabergoline is an ergot medication and works by blocking the release of prolactin from the pituitary gland.
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