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In hemodynamic studies in patients with essential hypertensionblood pressure reduction was accompanied by a reduction in peripheral arterial resistance with little or no change in cardiac output and in heart rateIn a study in 9 hypertensive patientsfollowing administration of lisinoprilthere was an increase in mean renal blood flow that was not significantData from several small studies are inconsistent with respect to the effect of lisinopril on glomerular filtration rate in hypertensive patients with normal renal functionbut suggest that changesif anyare not large.

Patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitorsee Contraindications

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