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In manan activity in both partial and generalised epilepsy conditionsepileptiform discharge/photoparoxysmal responsehas confirmed the broad spectrum pharmacological profile of levetiracetam.

Anyone considering prescribing KEPPRA or any other AED must balance the risk of suicidal thoughts or behaviors with the risk of untreated illnessEpilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behaviorShould suicidal thoughts and behavior emerge during treatmentthe prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated.

Table 3 lists adverse reactions that occurred in at least 1of adult epilepsy patients receiving KEPPRA in placebocontrolled studies and were numerically more common than in patients treated with placeboIn these studieseither KEPPRA or placebo was added to concurrent AED therapy.

KEPPRA is contraindicated in patients with a hypersensitivity to levetiracetamReactions have included anaphylaxis and angioedemasee WARNINGS AND PRECAUTIONS

The active substance in Keppralevetiracetamis an anti-epileptic medicineEpilepsy is caused by excessive electrical activity in the brainThe exact way in which levetiracetam works is still unclear but it seems to interfere with a protein called synaptic vesicle protein 2Awhich is found in the spaces between nerves and is involved in the release of chemical messengers from nerve cellsThis helps Keppra to stabilise electrical activity in the brain and prevent seizures.

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