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101 a paper reporting the experience of a brisbane mastalgia clinic also confirmed the efficacy of danazol in practice, with an overall success rate of 67 compared with the rates of 30 40 for other agents.

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Danazol may aggravate epilepsy and expose the condition in those so predisposed.

Danazol should be given as a continuous coursedosage being adjusted according to the severity of the condition and the patient’s responseA reduction in dosage once a satisfactory response has been achieved may prove possibleIn fertile femalesDanazol should be started during menstruationpreferably on the first dayto avoid exposing a pregnancy to its possible effectsWhere doubt existsappropriate checks should be made to exclude pregnancy before starting medicationFemales of child-bearing age should employ non-hormonal contraception throughout the course of treatment.

BMay be acceptableEither animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.

Heart diseasehigh blood pressurecoronary artery diseasecongestive heart failurehigh cholesterol or triglyceridesa history of breast cancerdiabeteshypoparathyroidismor low levels of calcium in your blooda seizure disorderkidney or liver diseaseor migraine headaches.

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