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Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorptionbioavailabilityof single doses of the followingcimetidinedigoxinfluoroquinolone antibioticsketoconazolel-thyroxinephenytoinquinidineranitidinetetracyclineand theophyllineSubtherapeutic prothrombin times with concomitant warfarin and sucralfate therapy have been reported in spontaneous and published case reportsHowevertwo clinical studies have demonstrated no change in either serum warfarin concentration or prothrombin time with the addition of sucralfate to chronic warfarin therapyThe mechanism of these interactions appears to be nonsystemic in naturepresumably resulting from sucralfate binding to the concomitant agent in the gastrointestinal tractIn all cases studied to datecimetidineciprofloxacindigoxinnorfloxacinofloxacinand ranitidinedosing the concomitant medication 2 hours before sucralfate eliminated the interactionDue to CARAFATE Oral Suspension’s potential to alter the absorption of some drugsCARAFATE Oral Suspension should be administeredseparately from other drugs when alterations in bioavailability are felt to be criticalIn these casespatients should be monitored appropriately.

Some medications may not work as well if you take them at the same time as sucralfateThey may need to be taken at a different time of the day than the time you take sucralfateAsk your doctor or pharmacist for help making a dosing schedule that will work with all your medications.

Take sucralfate on an empty stomachat least 1 hour before or 2 hours after a meal.

Shake the oral suspensionliquidwell just before you measure a doseMeasure the liquid with a special dose-measuring spoon or medicine cupnot with a regular table spoonIf you do not have a dose-measuring deviceask your pharmacist for one.

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