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A history of hormone-related canceror cancer of the breastuterus/cervixor vagina.
Certain estrogen products may also be used by women after menopause to prevent bone lossosteoporosisHoweverthere are other medicationssuch as raloxifenebisphosphonates including alendronatethat are also effective in preventing bone loss and may be saferThese medications should be considered for use before estrogen treatment.
Patients with a history of VTE or known thrombophilic states have an increased risk of VTEHRT may add to this riskHRT is therefore contraindicated in these patientssee section 4.3Personal or strong family history of thromboembolism or recurrent spontaneous abortion should be investigated in order to exclude a thrombophilic predisposition.
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