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Sinemet sr has an extradose function that can be used to manage acute off symptoms thatare not controlled by the morning dose and the continuous dose administeredover 16 hours.

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All patients should be observed carefully for the development of depression with concomitant suicidal tendencies.

Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptyingmetoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.

Levodopa has been detected in human milkCaution should be exercised when SINEMET is administered to a nursing woman.

If you plan to have surgery that needs a general anaesthetictell your doctor or dentist that you are taking SINEMET.

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