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During administration of losartanremoval of the angiotensin II negative feedback on renin secretion leads to increased plasma renin activityPRAIncrease in the PRA leads to an increase in angiotensin II in plasmaDespite these increasesantihypertensive activity and suppression of plasma aldosterone concentration are maintainedindicating effective angiotensin II receptor blockadeAfter discontinuation of losartanPRA and angiotensin II values fell within three days to the baseline values.
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