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In patients with normal renal functionchronic hypercalcemia may be associated with an increase in serum creatinineWhile this is usually reversibleit is important in such patients to pay careful attention to those factors which may lead to hypercalcemiaRocaltrolcalcitrioltherapy should always be started at the lowest possible dose and should not be increased without careful monitoring of the serum calciumAn estimate of daily dietary calcium intake should be made and the intake adjusted when indicated.

The dose of Rocaltrol should be carefully adjusted for each patient according to the biological response so as to avoid hypercalcaemia.

Rocaltrolcalcitriolis the most potent metabolite of vitamin D availableThe administration of Rocaltrolcalcitriolto patients in excess of their daily requirements can cause hypercalcemiahypercalciuriaand hyperphosphatemiaThereforepharmacologic doses of vitamin D and its derivatives should be withheld during Rocaltrolcalcitrioltreatment to avoid possible additive effects and hypercalcemiaIf treatment is switched from ergocalciferolvitamin D 2to calcitriolit may take several months for the ergocalciferol level in the bloodto return to the baseline valuesee OVERDOSAGE

Do not dispose of medications in wastewatere.gdown the sink or in the toiletor in household garbageAsk your pharmacist how to dispose of medications that are no longer needed or have expired.

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