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The trial’s primary outcome was the time to first occurrence of new ischemic strokefatal or notnew myocardial infarctionfatal or notor other vascular deathDeaths not easily attributable to nonvascular causes were all classified as vascular.

Take Plavix exactly as your doctor tells youDo not change your dose or stop taking Plavix without talking to your doctor firstStopping Plavix may increase your risk of heart attack or strokeTake Plavix with aspirin as instructed by your doctorIf you miss a dosetake Plavix as soon as you rememberIf it is almost time for your next doseskip the missed doseTake the next dose at your regular timeDo not take 2 doses of Plavix at the same time unless your doctor tells you toIf you take too much Plavixcall your doctor or go to the nearest emergency room right awayTalk with your doctor about stopping your Plavix before you have surgeryYour doctor may tell you to stop taking Plavix at least 5 days before you have surgery to avoid excessive bleeding during surgery.

Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole.

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