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Mestinonpyridostigmine bromide tabletsUSPis an orally active cholinesterase inhibitorChemicallypyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamateIts structural formula is:
Safety information for its use in pregnant or breastfeeding women is inadequateThe benefits and risks of the drug should be carefully considered before it is used among these women.
SMA is a genetic neurodegenerative disease that involves impairment of the neuromuscular transmissionSo Mestinonwhich facilitates the nerve signal transmission at the neuromuscular junctionNMJby inhibiting acetylcholine breakdowncould be a potential therapy for SMA.
The side effects of Mestinonpyridostigmineare most commonly related to overdosage and generally are of two varietiesmuscarinic and nicotinicAmong those in the former group are nauseavomitingdiarrheaabdominal crampsincreased peristalsisincreased salivationincreased bronchial secretionsmiosis and diaphoresisNicotinic side effects are comprised chiefly of muscle crampsfasciculation and weaknessMuscarinic side effects can usually be counteracted by atropinebut for reasons shown in the preceding section the expedient is not without dangerAs with any compound containing the bromide radicala skin rash may be seen in an occasional patientSuch reactions usually subside promptly upon discontinuance of the medication.
Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.
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