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There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetamThereforemacrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.
Antiepileptic drugsincluding KEPPRAshould be withdrawn gradually to minimize the potential of increased seizure frequency.
The administration of levetiracetam to patients with renal impairment may require dose adjustmentIn patients with severely impaired hepatic functionassessment of renal function is recommended before dose selectionsee section 4.2
Table 3Adverse Reactions in Pooled Placebo-ControlledAdd-On Studies in Adults Experiencing Partial Onset Seizures.
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
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