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in a pharmacokinetic trial where hiv-1 negative cirrhotic subjects with mild child-pugh a; n 6 or moderate child-pugh b; n 4 hepatic impairment received a single 200 mg dose of immediate-release viramune, a significant increase in the auc of nevirapine was observed in one subject with child-pugh b and ascites suggesting that patients with worsening hepatic function and ascites may be at risk of accumulating nevirapine in the systemic circulation.
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